Davis Senior High School is one of four high schools located in Davis, California, in the United States. DHS is a WASC accredited, 3-year, public comprehensive high school covering grades 10-12.

Wilmington High School is a public high school in Wilmington, Ohio. It is the only high school in the Wilmington City Schools district.

William Henry Harrison High School (also known as Harrison High School) is a public senior high school located in Harrison, Ohio. It is the only high school in the Southwest Local School District and serves as the high school for students located in Harrison Township, Crosby Township, and Whitewater Township in Hamilton County as well as a small section of Morgan Township in southwest Butler County. The district and school are ranked as "excellent" by the Ohio Board of Education.

Langley High School is a high school within the Fairfax County Public Schools system in Northern Virginia. It is located in McLean, a census-designated place in northern Fairfax County. The campus is located less than a mile west of the Central Intelligence Agency headquarters.

Michael E. DeBakey High School for Health Professions is a medical secondary school located in the Medical Center area of Houston, Texas, United States. It is a part of the Houston Independent School District.

Valley High School is a public high school located in West Des Moines, Iowa. VHS is a three-year comprehensive high school.

Middle Creek High School is one of six public high school in Cary and is part of the Wake County Public School System.

Ingraham High School is a public high school, serving grades 9–12 in the Haller Lake neighborhood of Seattle, Washington. Opened in 1959, the school is named after Edward Sturgis Ingraham, the first superintendent of the Seattle Public Schools.

Rock Hill High School is a public high school in Frisco, Texas in the United States. Although the school is located in Frisco, it mostly serves students from Prosper and McKinney.

Wellesley High School is located in Wellesley, Massachusetts.

Stoney Creek High School is a public high school located in Rochester Hills, Michigan and is part of the Rochester Community Schools school district.

Villa Joseph Marie High School is a private Roman Catholic all-girls high school in Holland, Pennsylvania.

Berea–Midpark High School is a public high school in Berea, Ohio, and is the only high school in the Berea City School District. 

Research Triangle High School, commonly abbreviated RTHS, is a charter school with a STEM focus located in Research Triangle Park, North Carolina.

Shelton High School is located in Shelton, Connecticut.

Voyager Academy is a public charter school in Durham, North Carolina.

Regis High School is a private, all-male, Jesuit secondary school located on the Upper East Side of Manhattan in New York City.

Central Valley Christian Schools is a private Christian school in Visalia, California. It was established as an elementary school in 1979 with a high school being added in 1982.

Americas High School is a high school in El Paso, Texas.

Homeschool students in the state of Minnesota.